MARC状态：待编 文献类型：电子图书 浏览次数：30
- 题名/责任者:
- Metal Response in Cupriavidus metallidurans Volume II: Insights into the Structure-Function Relationship of Proteins / by Guy Vandenbussche, Max Mergeay, Rob Van Houdt.
- 版本说明:
- 1st ed. 2015.
- 出版发行项:
- Cham : Springer International Publishing : Imprint: Springer, 2015.
- ISBN:
- 9783319206240
- 其它标准号:
- 10.1007/978-3-319-20624-0
- 载体形态项:
- VII, 70 p. 12 illus., 10 illus. in color. online resource.
- 其他载体形态:
- Printed edition: 9783319206257
- 其他载体形态:
- Printed edition: 9783319206233
- 丛编说明:
- SpringerBriefs in Biometals, 2212-9901
- 丛编统一题名:
- SpringerBriefs in Biometals,
- 个人责任者:
- Vandenbussche, Guy. author.
- 附加个人名称:
- Mergeay, Max. author.
- 附加个人名称:
- Van Houdt, Rob. author.
- 附加团体名称:
- SpringerLink (Online service)
- 论题主题:
- Microbiology.
- 论题主题:
- Geobiology.
- 论题主题:
- Applied Microbiology.
- 论题主题:
- Microbiology.
- 论题主题:
- Biogeosciences.
- 内容附注:
- Introduction -- Bacterial cation transporters and their representatives in Cupriavidus metallidurans -- Primary active transport -- Secondary active transport -- Structural efforts on C. metallidurans CH34 proteins involved in the response to meta lions -- HME-RND-driven systems -- Small periplasmic proteins -- Regulatory proteins -- Concluding remarks -- References.
- 摘要附注:
- This book is the second volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this second volume, the structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury. In addition, the first volume sketches the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. It provides a detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands.
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